Trainee Rounds: Dr. Sun-Ho Lee
DATE: December 12, 2022
TIME: 12pm to 1pm
METHOD: Zoom
PRESENTER: Dr. Sun-Ho Lee
REGISTRATION: https://us06web.zoom.us/meeting/register/tZcrf-ChrDMoG9XiPTCHXdN-MxJFXSeZ9XRy
Dr. Sun-Ho Lee
Advanced Inflammatory Bowel Disease Fellow, MD, PhD - Temerty Faculty of Medicine
University of Toronto, Division of Gastroenterology and Hepatology
Title of Talk
"Machine learning-based microbiome risk model predicts future development of Crohn’s disease among healthy first-degree relatives"
Abstract
Crohn’s Disease (CD) is characterized by chronic, relapsing inflammation of the intestine. The cause of CD is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation and damage. The Crohn's and Colitis Canada Genetic Environmental Microbial (GEM) project, a prospective cohort study of healthy first-degree relatives (FDRs) of CD, was designed to identify the parameters associated with the development of CD. We applied a machine learning approach to the analysis of the gut microbiome composition in a large cohort of healthy FDRs of CD patients (n=3483) to define a microbial signature that is associated with the risk of developing CD.
Biography
Dr. Lee is a certified gastroenterologist with a special interest in Inflammatory Bowel Disease. He further trained as an Advanced IBD Fellow at Mount Sinai Hospital and during this time he completed his PhD at the Institute of Medical Science at the University of Toronto. He has been part of the Crohn's Colitis Canada GEM Project Research Team, a project that aims to understand the pre-clinical phase of Crohn's disease. Using his biostatistics and bioinformatics skills, he has explored the interaction of host genetics, gut microbiome, anti-microbial immune response, and the gut barrier function and how it relates to future development of IBD.
Learn More
Twitter: @SunHoLee15
